publications

​AT SCRIPPS RESEARCH

 A review article discussing the various methods and applications of cell surface glycan engineering, it's history and future directions.

We present the use of in situ proximity labeling as a powerful approach to tag the dynamic glycoprotein interactors for galectin-3 in the context of living hepatic stellate cells. 

 A review article surveying modern approaches towards the identification and analysis of glycan-protein intereractions. 

 A conference report summarizing the discussions held at the Nanolithography of Biointerfaces Faraday Discussion in London, UK. 

A companion protocol article to accompany our work on the small molecule, surfen, which antagonizes cell surface heparan sulfate to maintain the pluripotency of mouse embryonic stem cells in culture.

​POSTDOCTORAL WORK AT UC SAN DIEGO​

25. Influencing Early Stages of Neuromuscular Junction Formation through Glycocalyx Engineering

ML Huang, EM Tota, TM Lucas, K Godula 

ACS Chem Neuro. (2018) 9:3086.

24. Embryonic Stem Cell Engineering with a Glycomimetic FGF2/BMP4 Co-Receptor Drives Mesodermal Differentiation in a Three-Dimensional Culture.

MR NaticchiaLK LaubachEM TotaTM LucasML HuangK Godula*

ACS Chem. Biol. (2018) 13:2880.

23. Glycocalyx scaffolding to control cell surface glycan displays. 

ML Huang, EM Tota, S Verespy. 

Curr Prot Chem Biol (2018) 10:e40.

22. Heparin-fibronectin interactions in the development of extracellular matrix insolubility. 

I Raitman, ML Huang, SA Williams, B Friedman, K Godula, JE Schwarzbauer. 

Matrix Biol (2018) 67:107.

21. Small molecule antagonist of cell surface glycosaminoglycans restricts embryonic stem cells in a pluripotent state. 

ML Huang, AL Michalak, CJ Fisher, M Christy, RAA Smith, K Godula.

Stem Cells (2018) 36:45.

 

20. Glycocalyx scaffolding with synthetic nanoscale glycomaterials.

ML Huang, S Purcell, S Verespy, Y Wang, K Godula. 

Biomat Sci (2017) 5:1537.

19. Human milk oligosaccharides inhibit growth of group B Streptococcus. 

AE Lin, CA Autran, A Szyszka, T Escajadillo, ML Huang, K Godula, AR Prudden, G-J Boons, AL Lewis, KS Doran, V Nizet, L Bode.

J Biol Chem (2017) 292:11243.

18. Synthetic mucus nanobarriers for identification of glycan-dependent primary Influenza A infection inhibitors. 

M Cohen, HP Senaati, CJ Fisher, ML Huang, P Gagneux, K Godula. 

ACS Cent Sci (2016) 2:710.

17. Capture and characterization of influenza A virus from primary samples using glycan bead arrays. 

M Cohen, CJ Fisher, ML Huang, LL Lindsay, M Plancarte, WM Boyce, K Godula, P Gagneux. 

Virology (2016) 493:128.

16.  Glycomaterials in immunology: exploring the roles of glycans integral to pathogen interactions and the accompanying host immune response.

ML Huang, CJ Fisher, K Godula. 

Exp Biol Med (2016) 241:1042.

15.  Nanoscale materials for probing the biological functions of the glycocalyx. 

ML Huang, K Godula. 

Glycobiology (2016) 26:797.

14.   Glycocalyx remodeling with glycopolymer-based proteoglycan mimetics. 

ML Huang, RA Smith, GW Trieger, K Godula. 

Methods Mol Biol (2016) 1367:207.

13.   Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

ML Huang, M Cohen, CJ Fisher, RT Schooley, P Gagneux, K Godula. 

Chem Commun (2015) 51:5326. 

12.  Priming the cellular glycocalyx for neural development. 

ML Huang, K Godula. 

ACS Chem Neurosci (2014) 5:873.

11.  Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells. 

ML Huang,* RA Smith,* GW Trieger, K Godula. * equal authorship

J Am Chem Soc (2014) 136:10565. 

 

GRADUATE WORK AT NEW YORK UNIVERSITY

10.  Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes. 

K Andreev, MW Martynowycz, ML Huang, I Kuzmenko, B Wu, K Kirshenbaum, D Gidalevitz. 

BBA-Biomembranes (2018) 1860:1414.

9.    Cyclization improves membrane penetration by antimicrobial peptoids. 

K Andreev, M Martynowycz, A Ivankin, ML Huang, I Kuzmenko, M Meron, B Lin, K Kirshenbaum, D Gidalevitz. 

Langmuir (2016) 32:12905.

8.    Osmoprotective polymer additives attenuate the membrane pore forming activity of antimicrobial peptoids. 

PT Smith, ML Huang, K Kirshenbaum.

Biopolymers (2015) 103:227. 

7.    Amphiphilic cyclic peptoids that exhibit antimicrobial activity by disrupting Staphylococcus aureus membranes. 

ML Huang, MA Benson, SBY Shin, VJ Torres, K Kirshenbaum. 

Eur J Org Chem (2013) 17:3560. 

6.    Engineered biomimetic oligomers as dual-action antifreeze agents. 

ML Huang, D Ehre, K Kirshenbaum, MD Ward. 

Proc Natl Acad Sci (2012) 109:19922. 

5.    N-naphthyl peptoid foldamers exhibiting atropisomerism. 

B Paul, GL Butterfoss, MG Boswell, ML Huang, R Bonneau, C Wolf, K Kirshenbaum. 

Org Lett (2012) 14:926.

4.    A comparison of linear and cyclic peptoids as potent antimicrobial agents. 

ML Huang, SBY Shin, MA Benson, VJ Torres, K Kirshenbaum. 

ChemMedChem (2012) 7:114.

3.    Peptoid macrocycles: making the rounds with peptidomimetic oligomers. 

B Yoo, SBY Shin, ML Huang, K Kirshenbaum. 

Chem Eur J (2010) 16:5528.

 

UNDERGRADUATE WORK AT CUNY QUEENS COLLEGE

2.    Synthesis and properties of polycationic derivatives of carbohydrates. 

M Thomas, D Montenegro, A Castano, L Friedman, J Leb, ML Huang, L Rothman, H Lee, C Copodiferro, D Ambinder, E Cere, J Galante, JI Rizzo, K Melkonian, R Engel. 

Carbohydr Res (2009) 344:1620.

1.    The synthesis of polycationic lipid materials based on the diamine 1,4-diazabicyclo[2.2.2]octane. 

R Engel, JI Rizzo, C Rivera, M Ramirez, ML Huang, D Montenegro, C Copodiferro, V Behaj, M Thomas, B Klaritch-vrana, JF Engel. P

Chem Phy Lipids (2009) 158:61.

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